![]() ![]() ![]() Ischemic heart disease (IHD) is a significant challenge among middle-aged individuals without diabetes. Additionally, sex differences may merit serious consideration when interpreting TG/HDL-C for assessing cardiovascular risks in clinical practice. Compared with metabolic syndrome, TG/HDL-C had a more powerful predictive value for IHD.Ĭonclusions: In Koreans without diabetes, an increased TG/HDL-C precedes future IHD. Compared with men, women showed higher HRs for the risk of incident IHD in the fourth quartile and 1.80, respectively). Results: During the follow-up period, 321 (2.0%) participants developed IHD. ![]() Using multivariate Cox proportional-hazards regression models, we prospectively examined the hazard ratios (HRs) with 95% confidence intervals (CIs) for IHD over 50 months after baseline enrolment. Participants were classified based on the TG/HDL-C quartiles. Methods: We assessed 16,455 individuals (8,426 men and 8,029 women) without diabetes in a community-dwelling Korean cohort using National Health Insurance data. ![]() This study aimed to investigate the effects of the triglyceride to high-density lipid (HDL)-cholesterol ratio (TG/HDL-C), which could reflect insulin resistance from the beginning, on the incident risk of ischemic heart disease (IHD). 4Department of Family Medicine, Gangnam Severance Hospital, Seoul, South Koreaīackground: Early insulin resistance without diabetes can cause cardiovascular disease, which is a public health challenge.3Biostatistics Collaboration Unit, Department of Research Affairs, Yonsei University College of Medicine, Seoul, South Korea.2Department of Family Medicine, Yonsei University College of Medicine, Seoul, South Korea.1Department of Family Medicine, Yongin Severance Hospital, Seoul, South Korea.Byoungjin Park 1,2 † Dong Hyuk Jung 1,2 † Hye Sun Lee 3 Yong Jae Lee 2,4 * ![]()
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